| abstract |
The present invention relates to administering a retinoic acid derivative or a pharmaceutically acceptable salt thereof, and a retinoid that produces ceramide containing D-threo-PPMP or a pharmaceutically acceptable salt thereof as a ceramide degradation inhibitor. And wherein the hyperproliferative disease is a tumor; and a retinoid that produces ceramide is administered in an effective amount to cause necrosis, apoptosis, or both in the tumor, and ceramide The degradation inhibitor is administered in an effective amount to increase necrosis, apoptosis, or both, more than would be expected to result from the sum of ceramide-producing retinoid and ceramide degradation inhibitor when administered separately. |