| abstract |
In many embodiments, the present invention provides a novel class of bipiperidinyl compounds as inhibitors of CCR5 receptors, methods for preparing such compounds, pharmaceutical compositions comprising one or more such compounds, one or more Of preparing a pharmaceutical formulation comprising such a compound, and methods of treating, preventing, inhibiting or alleviating one or more diseases associated with CCR5 using such compound or pharmaceutical composition provide. The invention also relates to the use of a combination of a compound of the invention with one or more antiviral agents or other agents useful in the treatment of human immunodeficiency virus (HIV). The invention further provides for the treatment of solid organ transplant rejection, graft versus host disease, arthritis, rheumatoid arthritis, inflammatory bowel disease, atopic dermatitis, psoriasis, asthma, allergy or multiple sclerosis, alone or It relates to the use of a compound of the invention in combination with another agent. |