| abstract |
A drug delivery system for delivering a biologically active agent through a patient's skin is (i) a pretreatment patch adapted to be placed on the patient's skin, wherein the pretreatment patch is a backing membrane And a plurality of microprojections, wherein the microprojection array is adhered to the backing membrane, the microprojection array being adapted to penetrate the stratum corneum of the patient, and the pretreatment patch is the patient's skin A pretreatment patch and (ii) a gel patch having a top layer and a bottom layer, wherein the gel patch includes a skin template that is applied to and removed from the skin before the pretreatment patch remains on the patient's skin, Here the gel patch includes a reservoir containing the hydrogel preparation, and the gel patch is about 0 And it has a skin contact area in the range of 5 to 30 cm 2, comprising gel patch, a. |