| abstract |
The present invention relates generally to the fields of genetics, biochemistry, medicinal chemistry and medicine. The present invention more particularly identifies human genetic variants associated with neuropathological conditions, and methods for the diagnosis, prevention and treatment of such diseases and related disorders, and screening for therapeutic active agents. A method for is disclosed. The present invention relates to a β-secretase (memapsin 2, BACE) mutant having catalytic activity, and a nucleic acid encoding the same. The present invention is useful for the identification of drugs that inhibit the activity of specific BACE isoforms, and therefore for the identification of drugs and therapies that affect the development, development or progression of neuropathological conditions including Alzheimer's disease and dementia. . [Selection] Figure 5 |