| abstract |
Treatment of patients with a neurosteroid of formula (I) reduces opioid tolerance. In which R 1 is H or methyl; R 2 is OH; R 3 is H or R 2 and R 3 together are O; R 4 is H or methyl And R 5 and R 6 are each H, or R 5 and R 5 taken together are O; R 7 is H or methyl; and R 8 is H, OH, —OC (= O) CH 3 , SH, —SC (═O) CH 3 , Cl, Br, or F. |