| abstract |
The present invention relates to a method for producing a painless sensation in a mammal. This method is based on the subject of an omega conopeptide, preferably ziconotide, an analgesic selected from the group consisting of morphine, bupivacaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine and sufentanil, or a pharmaceutically acceptable salt thereof. In which the ω-conopeptide retains its potency and is physically and chemically compatible with the analgesic. A preferred route of administration is intrathecal administration, particularly continuous intrathecal infusion. The invention also relates to a pharmaceutical formulation comprising an omega conopeptide, preferably ziconotide, together with an analgesic selected from morphine, bupivacaine, clonidine, hydromorphone, baclofen, fentanyl, buprenorphine and sufentanil. |