| abstract |
The present invention provides human AdipoR2 associated with cardiovascular disease, skin disease, gastrointestinal disease, cancer, blood disease, respiratory disease, inflammation, nervous system disease, urological disease. The present invention also provides an assay for the identification of compounds useful for the treatment or prevention of cardiovascular disease, skin disease, gastrointestinal disease, cancer, blood disease, respiratory disease, inflammation, nervous system disease, urological disease. . The invention further features compounds that bind to AdipoR2 and / or compounds that activate or inhibit the activity of AdipoR2, and pharmaceutical compositions comprising such compounds. |