| abstract |
The present invention relates to a quinazoline derivative of formula (I), wherein each of R 1 , R 2 , W, X 1 , X 2 , Z, a and b is as defined in the description; A pharmaceutical composition containing them and its use in the manufacture of a medicament for providing an antiproliferative effect. The quinazoline derivatives of formula (I) are expected to be useful in the treatment of certain diseases such as cancer mediated by erbB receptor tyrosine kinases, particularly EGFR tyrosine kinases. |