| abstract |
Compounds, compositions and methods are provided that are useful in treating diseases by modulating potassium ion flux through voltage-gated potassium channels. More specifically, the invention regulates central or peripheral nervous system disorders (e.g., migraine, ataxia, Parkinson's disease, by modulating potassium channels associated with the onset or recurrence of the indicated condition. Bipolar disorder, trigeminal neuralgia, spasticity, mood disorder, brain tumor, psychiatric disorder, myokiemia, seizures, epilepsy, hearing and vision loss, Alzheimer's disease, memory decline with age, learning impairment, anxiety and motor neuron disease, maintenance of bladder control Also provided are quinazolinones, compositions and methods useful in treating (or treating urinary incontinence) and useful as neuroprotective agents (eg, preventing strokes, etc.). |