| abstract |
The present invention relates to a compound of formula (I) [Wherein, A and B represent — (CH 2 ) m — and — (CH 2 ) n — groups, respectively; R 1 represents hydrogen or C 1-6 alkyl; R 2 represents hydrogen, Halogen, hydroxy, cyano, nitro, hydroxy C 1-6 alkyl, trifluoromethyl, trifluoromethoxy, C 1-6 alkyl, C 1-6 alkoxy, C 1-6 fluoroalkoxy, — (CH 2 ) p C 3 -6 cycloalkyl, - (CH 2) p OC 3-6 cycloalkyl, -COC 1-6 alkyl, -SO 2 C 1-6 alkyl, -SOC 1-6 alkyl, -S-C 1-6 alkyl, —CO 2 C 1-6 alkyl, —CO 2 NR 3 R 4 , —SO 2 NR 3 R 4 , — (CH 2 ) p NR 3 R 4 , — (CH 2 ) p NR 3 COR 4 , substituted May Reel ring, optionally substituted heteroaryl ring, fused bicyclic represents an aromatic heterocyclic ring system or heterocyclic ring which may be substituted; Ar 1 represents a heteroaryl ring which may be substituted; Ar 2 represents an optionally substituted aryl ring or an optionally substituted heteroaryl ring; Z represents — (CH 2 ) q X— (wherein the — (CH 2 ) q — group represents Ar 2 ) or —X (CH 2 ) q — (wherein X is bonded to Ar 2 ), wherein any of the —CH 2 — groups is one or more C Optionally substituted by a 1-6 alkyl group; X represents oxygen, —CH (OR 5 ) —, —NR 5 — or —CH 2 —, wherein the —CH 2 — group is one or more It may be substituted by C 1-6 alkyl group; R 3 and Each 4, independently, hydrogen, C 1-6 represents an alkyl, or they taken together with the nitrogen or other atoms are bonded, azacycloalkyl ring or an oxo-substituted azacycloalkyl ring R 5 represents hydrogen or C 1-6 alkyl; m and n independently represent an integer selected from 1 and 2; p independently represents 0, 1, 2 And q independently represents an integer selected from 0, 1, 2 and 3; provided that Ar 1 is a pyridyl group and Z is —CH 2 X— ( Wherein X is bound to the Ar 1 group), X is selected from —CH (OR 5 ) —, —NR 5 — and —CH 2 —, wherein the —CH 2 — The group may be substituted by one or more C 1-6 alkyl groups] Or a pharmaceutically acceptable salt or solvate thereof. The compounds of formula (I) are useful in therapy, in particular as antipsychotic agents. |