| abstract |
Many metal chelators have polar or charged functional groups that make passage through the cell membrane difficult. The polyamine / metal chelator conjugate of the present invention comprises a first portion that is a metal chelator and a second portion that is a polyamine, the polyamine portion comprising three or more nitrogen atoms that can be positively charged at physiological pH. A compound. Spermine / L1 conjugates were shown to accumulate several hundred times more in L1210 cells than uncomplexed L1 chelators. The present invention relates to a compound comprising a first part that is a metal chelator and a second part that is a polyamine, wherein the polyamine part contains three or more nitrogen atoms that can be positively charged at physiological pH, or a salt thereof. , Solvates or hydrates. |