| abstract |
The present invention relates to modulators of ATP-binding cassette (“ABC”) transporters or fragments thereof, including CF transmembrane regulators (“CFTR”), compositions thereof, and methods using them. The invention also relates to methods of treating ABC transporter mediated diseases using such modulators. The present invention provides a method of modulating ABC transporter activity. This method comprises contacting the ABC transporter with a compound of formula I or formula I 'or a pharmaceutically acceptable salt thereof. |