| abstract |
The present invention describes the application of sirolimus and sirolimus analogs to treat wound healing and to reduce scar tissue formation. The present invention also contemplates non-sirolimus compounds that are believed to interact with mTOR proteins with similar effects. In particular, various media for making microparticles, foams, gels, sprays, and bioadhesives that can be administered during surgical procedures involving, for example, either open or closed surgical sites are contemplated. Coated medical devices for long-term implantation are contemplated as one method of using the composition. |