| abstract |
The present invention relates to the discovery of a new family of enzymes that exhibit endoribonuclease activity, referred to herein as mRNA interferases. Thus, the novel finding of the present invention represents a novel application that can benefit from the use of mRNA interferase nucleic acid and amino acid sequences and compositions thereof. The invention also includes screening methods and methods of using such compounds / agents to identify compounds / agents that can modulate mRNA interferase activity. Also provided is a kit comprising the mRNA interferase nucleic acid and / or amino acid sequence, an mRNA interferase activity compatible buffer, and instructions. |