| abstract |
In SNP analysis, DNA hybridization is utilized and a DNA chip is used. Specifically, the liquid DNA probe to be analyzed is guided onto the DNA chip in a predetermined time course. After hybridization is performed under low stringent conditions, the temperature is changed so that the capturer DNA-target DNA hybrid is melted, and the capturer DNA-target DNA hybrid is melted at temperature. Dependently detected and evaluated. In addition to the known DNA chip (1), there is at least one temperature control or temperature control device (10) and a lateral flow device (20, 30) on the surface (2) of the DNA chip (1). . By means of suitable measurement means, factors for hybrids that match each other (match) and non-matches (mismatch / one point mismatch) can be detected and evaluated. |