| abstract |
Formula (I) [Chemical 1] Leukotriene A4 hydrolase (LTA4H) inhibitors represented by the following, compositions containing them, and the purpose of inhibiting LTA4H enzyme activity and treating, preventing or suppressing inflammation and / or diseases related to inflammation Use for purposes. Wherein X is NR 5 [R 5 is one of H and CH 3 ], selected from the group consisting of O and S, Y is selected from the group consisting of CH 2 and O, and W Is selected from the group consisting of CH 2 and CHR 1 —CH 2, wherein R 1 is one of H and OH, wherein R 1 is bound to R 1 in said CHR 1 —CH 2 Carbon members are not directly bonded and R 4 is selected from the group consisting of H, OCH 3 , Cl, F, Br, OH, NH 2 , CN, CF 3 and CH 3 ; 6 is H or F, and R 2 and R 3 are each independently selected from various groups. |