abstract |
PROBLEM TO BE SOLVED: To provide a preventive / therapeutic agent for a neurodegenerative disease (for example, polyglutamine disease). An HMGB family protein or a derivative thereof, for example, a protein described in the following (a) or (b) is contained in a prophylactic / therapeutic agent for a neurodegenerative disease. (A) a protein comprising the amino acid sequence described in SEQ ID NO: 2, 4, 6 or 8 (b) one or more amino acids in the amino acid sequence described in SEQ ID NO: 2, 4, 6 or 8 are deleted, substituted, added A protein consisting of an inserted amino acid sequence and having a binding activity to an abnormal polyglutamine protein that occurs in neurodegenerative diseases [selection figure] None |