| abstract |
PROBLEM TO BE SOLVED: To provide specific binding members, particularly antibodies and active fragments thereof, that recognize abnormal post-translationally modified forms of EGFR, particularly abnormal glycosylated forms. An isolated specific binding member, wherein the isolated specific binding member recognizes an EGFR epitope, wherein the EGFR epitope is any amino acid sequence change from normal EGFR. Or an isolated specific binding member that does not show amino acid sequence substitutions and that the EGFR epitope is found in tumorigenic cells, hyperproliferative cells or abnormal cells and cannot be detected in normal cells . [Selection figure] None |