| abstract |
PROBLEM TO BE SOLVED: To provide a potent antagonist for chemokines, particularly RANTES, which play an important role in inflammatory diseases. Synthetic chemokines such as RANTES G1755, G1805, and G1806, which have a water-soluble polymer attached to the N-terminus and / or C-terminus, and are characterized by in vitro modulation of the corresponding receptor. Synthetic chemokines with biological activity. The water-soluble polymer is a polysaccharide such as dextran or a synthetic polymer such as polyethylene glycol, and the chemokine N-terminus / C-terminus is modified with a portion such as an aliphatic chain, an amino acid and an amino acid derivative. [Selection] Figure 1A |