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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00
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filingDate 2007-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fbb8ca71a5c1689a69294b8495590c43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_330c6007c57c6b20cbd67f252e303ee5
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publicationDate 2007-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2007277224-A
titleOfInvention Process for producing trans-4-amino-1-methylcyclohexanols
abstract Disclosed is a process for producing trans-4-amino-1-methylcyclohexanol which can be produced industrially at a high yield and at a low yield by improving the production ratio of trans: cis. A process for producing trans-4-amino-1-methylcyclohexanols of formula 4 or salts thereof according to the following steps. [Wherein, R 1 and R 2 each independently represent a hydrogen atom or an amino-protecting group. ] [Step 1] A step of producing a compound of formula 2 by reacting 4-aminocyclohexanones of formula 1 with dimethylsulfonium methylide. [Step 2] A step of producing a compound of formula 3 by reducing a compound of formula 2. [Step 3] A step of separating the trans isomer in the compound of Formula 3 or a salt thereof to obtain the compound of Formula 4. [Step A] A step of deprotecting an amino-protecting group in the compound of Formula 2, Formula 3 or Formula 4 following any one of Steps 1 to 3 as necessary. [Selection figure] None
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009054347-A1
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type http://data.epo.org/linked-data/def/patent/Publication

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