| abstract |
【Task】 Aiming to supply inexpensive products to the medical field by developing a simpler method for producing the antitumor anthracycline antibiotic epirubicin than ever before and providing an industrial and low-cost production method To do. [Solution] 4'-epidaunorubicin or a salt thereof is reacted with a brominating agent in the presence of a ketalizing agent to obtain a bromoketal compound, then treated with a ketone solvent under acidic conditions to obtain a bromoketone compound, and further a carboxylic acid A method for producing epirubicin, characterized in that epirubicin or a salt thereof is obtained by hydrolysis in the presence of a metal salt. |