Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aec226d7e52cce771f1689e347e8525e |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0735 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61L27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
filingDate |
2006-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e63b90b8bffdc41fac80c5998ebfa5e5 |
publicationDate |
2007-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2007252220-A |
titleOfInvention |
Method for producing cardiomyocytes and differentiation inducer |
abstract |
The present invention provides a method for inducing differentiation of undifferentiated stem cells into cardiomyocytes selectively at a high rate. [MEANS FOR SOLVING PROBLEMS] A candidate molecule that promotes differentiation induction from a stem cell to a cardiomyocyte can be identified by searching for a gene whose expression level increases upon induction of differentiation into an embryonic cancer cell (EC cell) into a cardiomyocyte. went. As a result, a bone morphogenetic factor (BMP-5) or a secretory inhibitor of Wnt signal (sFRP-5) was found as a substance whose expression level is temporarily increased upon induction of myocardial differentiation in an embryonal cancer cell line. . Stem cells are cultured under the action of the substance within 10 days from the start of induction of myocardial differentiation in an embryonal cancer cell line. [Selection figure] None |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8658425-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10196609-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233426-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9587220-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009136209-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9499790-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104407149-A |
priorityDate |
2006-03-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |