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filingDate 2007-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1c41b0af5f308f1ef0e78119a3f26a6
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publicationDate 2007-09-06-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2007222170-A
titleOfInvention Inhibition of binding between MDM2 and p53 protein and its therapeutic application
abstract An immunochemical characterization of a p53-MDM2 (oncogene protein) complex that acts to inactivate the tumor suppressor p53 and provides details of the MDM2 binding site on p53. Provided is a polypeptide that contributes to the binding to MDM2 and does not exceed 28 amino acids of the p53 protein and includes a portion containing the amino acid sequence QETFSDLWKL, or a variant carrying the same, and this poly Providing a DNA sequence encoding the peptide. [Selection figure] None
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