| abstract |
[PROBLEMS] To prevent tissue damage and cell necrosis by drug administration, and is an effective marker for considering pharmacokinetics of various drugs. To provide a biomarker that can be detected. SOLUTION: The blood concentration of ophthalmic acid, which is a substance that varies in blood according to the variation in the concentration of reduced glutathione (GSH) in a biological sample, is measured with an analyzer such as a capillary electrophoresis-mass spectrometer. Whether or not it is oxidative stress is determined. Antioxidant stress candidate drugs are administered to non-human animals in an oxidative stress state, blood levels of ophthalmic acid are measured, and the degree of decrease in ophthalmic acid concentration is evaluated to screen for antioxidative stress agents To do. [Selection figure] None |