| abstract |
PROBLEM TO BE SOLVED: To provide a novel intermediate in a method for preparing a 2-oxo-1-pyrrolidine derivative. SOLUTION: General formula (A) (In the above formula, X is -CONR 5 R 6 , or -COOR 7 , or -CO-R 8 , or CN, R 1 is hydrogen or the like, and R 2 and R 4 are the same or different and are each independently R 3 is hydrogen, R 5 , R 6 , R 7 are the same or different and are each independently hydrogen, R 8 is hydrogen, etc.) And pharmaceutically acceptable salts thereof, provided that the compound is methyl 2- [4R, S-isopropyl-2-oxo-pyrrolidin-1-yl] acrylate and methyl 2- [3R, S-chloro -4R, S-isopropyl-2-oxopyrrolidin-1-yl] acrylate. [Selection figure] None |