| abstract |
PROBLEM TO BE SOLVED: To provide a piperidine compound having excellent tachykinin receptor antagonistic activity. The general formula [I] (In the formula, ring A represents a benzene ring which may have a substituent. Ring B represents a benzene ring which may have a substituent. R represents a hydrogen atom or an alkyl group which may have a substituent. X represents a group represented by —CO—, —SO— or —SO 2 —. m represents an integer of 1 or 0. R 1 represents an alkyl group which may have a substituent, a cycloalkyl group which may have a substituent, or the like. Z represents an oxygen atom or a group represented by —N (R 3 ) —. R 3 represents a hydrogen atom or an alkyl group which may have a substituent. R 4a and R 4b are the same or different and each represents a hydrogen atom or an alkyl group which may have a substituent, or a group which is bonded to each other at a terminal to form an alkylene group. ) Or a pharmacologically acceptable salt thereof. [Selection figure] None |