| abstract |
The present invention relates to a series of inflammations that increase EETs by inhibiting sEH activity, increase blood pressure based on vasodilatory action, renal diseases, cardiovascular diseases including cerebral infarction, and activation of NFκB / IκB kinase. The present invention provides an anilide derivative which is expected as a therapeutic agent for sex diseases or autoimmune diseases, as well as a therapeutic agent for endocrine metabolic diseases including hyperlipidemia and diabetes and adult respiratory distress syndrome. [Solution] [Wherein R 1 is a halogen atom; an optionally substituted C 1-18 alkyl group, etc .; R 2 and R 3 are the same or different and each represents a hydrogen atom, a halogen atom, a C 1-18 alkyl group which may be substituted with 1 to 4 halogen atoms, and the like, Ar 1 represents furan, thiophene, pyrrole, pyrazole, imidazole, oxazole, isoxazole, etc. R 9 and R 10 are the same or different and each represents a hydrogen atom, a halogen atom, an optionally substituted C 1-18 alkyl group or the like. Or a pharmaceutically acceptable salt or hydrate thereof. [Selection figure] None |