http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007104941-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_39a9f66181ba753d515b2c2ef8e707da |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-079 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edabdf93544e0a763ac6e251b084f835 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ff923e82619e7693c54197a80b5f5369 |
| publicationDate | 2007-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2007104941-A |
| titleOfInvention | Method for detecting gene expressed predominantly in cerebral vascular endothelial cells, protein encoded by the gene, and method for inhibiting cell death by knocking down the gene |
| abstract | Disclosed is a method for suppressing neuronal cell death, particularly in cerebral infarction, by inhibiting cell death promoting function safely and effectively. SOLUTION: BEC-1 gene expression when a neuronal cell death is induced by serum-free medium or 6-hydroxydopamine (6-OHDA), increase of protein encoded by the gene, and BEC-1 gene by RNAi method Delayed neuronal cell death when knocked down was observed. The screening method using the expression of this gene and the protein encoded by this gene as an index enables the development of new therapeutic agents such as pathological conditions mainly caused by cell death and neurodegeneration (eg Parkinson's disease, stroke, Alzheimer's disease). is there. In addition, this gene and the protein encoded by the gene may be able to suppress neuronal cell death in cerebral infarction or the like by inhibiting this function, which may be effective as an antitumor agent. [Selection] Figure 1 |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109609457-A |
| priorityDate | 2005-10-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 263.