| abstract |
The present invention provides a method for producing a medicament using a fusion of an Fc domain and a biologically active peptide and the biologically active peptide. A) selecting at least one peptide that alters the activity of the protein of interest; and b) a pharmacological agent comprising an Fc domain covalently linked to at least one amino acid of the selected peptide. A pharmacologically active compound is produced by a process comprising preparing. Binding to the vehicle increases the half-life of the peptide that would otherwise be rapidly degraded in vivo. A preferred vehicle is an Fc domain. Peptides are preferably selected by phage display, E. coli display, RNA-peptide screening, or chemical-peptide screening. [Selection figure] None |