| abstract |
Disclosed is a composition that inhibits the growth of cancer cells, particularly breast cancer, liver cancer, lung cancer or gastric cancer cells, and is useful for the treatment and diagnosis of tumors. A polypeptide comprising a specific amino acid sequence or an amino acid sequence having one to several amino acid substitutions, deletions or additions in the sequence is overexpressed in breast cancer, liver cancer, lung cancer or gastric cancer cells, A medicament comprising a therapeutically effective amount of an antibody (in particular, a monoclonal antibody, an antibody fragment, a chimeric antibody, or a humanized antibody) that binds to the polypeptide and exhibits an effect. Furthermore, a pharmaceutical that is conjugated to a cytotoxic agent (for example, maytansinoid, calicheamicin) to the antibody. A kit comprising an immunohistochemical analytical means for diagnosing the presence of a tumor using the antibody. [Selection] Figure 6 |