http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007074942-A

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filingDate 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_226a48dacc0964d2cd3ae2d0905bca0b
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publicationDate 2007-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2007074942-A
titleOfInvention Process for producing optically active penicillamine
abstract The present invention provides an efficient method for producing optically active L-penicillamine and D-penicillamine, which are important as intermediates for the production of various industrial chemicals, pharmaceuticals and agricultural chemicals. [MEANS FOR SOLVING PROBLEMS] A penicillamine amide, which is a DL mixture, is allowed to act on a microbial cell or a treated product of a microorganism having an activity of stereoselectively hydrolyzing the amide bond of L-penicillamine amide, and the produced L-penicillamine and the residue are reacted. The resulting D-penicillamine amide is reacted with an aldehyde, a ketone, or an acetal (ketal) to give thiazolidine-4-carboxylic acid and thiazolidine-4-carboxylic acid amide, respectively. By ringing, it becomes possible to produce high-quality optically active L-penicillamine and D-penicillamine at high yield and low cost. [Selection figure] None
priorityDate 2005-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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