| abstract |
A nanoparticle having a hydrated gel film functionalized with a polysaccharide, which is excellent in stability and sustained release effect of a protein drug, and can significantly reduce the initial burst of the drug, and a sustained release containing the nanoparticle A drug delivery system and a method for manufacturing the same are provided. SOLUTION: Nanoparticles comprising a biodegradable polymer, a biocompatible polymer emulsifier, and a polysaccharide, wherein an inner core and an external hydration in which the polysaccharide is physically fixed Provided is a nanoparticle having a hydrated gel film functionalized with a polysaccharide, the gel film comprising a gel film. [Selection] Figure 1 |