| abstract |
PROBLEM TO BE SOLVED: To provide a mammalian rapamycin target protein (mTOR) inhibitor containing a 4-aminoquinazoline derivative or a pharmacologically acceptable salt thereof, a 4-aminoquinazoline derivative having mTOR inhibitory activity or a pharmacologically acceptable salt thereof Provide salt. SOLUTION: General formula (I) [Chemical 6] (In the formula, R 1 and R 2 are the same or different and each represents a hydrogen atom, R 3 represents a hydrogen atom, R 4 represents a hydrogen atom, R 5 represents a substituted or unsubstituted aryl, etc. ) The mTOR inhibitor etc. which contain the 4-amino quinazoline derivative represented by these or its pharmacologically acceptable salt as an active ingredient are provided. [Selection figure] None |