http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2007008918-A

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filingDate 2006-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2007-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-2007008918-A
titleOfInvention Process for producing paroxetine hydrochloride hemihydrate
abstract A method for producing crystalline paroxetine hydrochloride hemihydrate that is readily applicable on an industrial scale and gives better results in terms of both yield and impurities. A method for producing crystalline paroxetine hydrochloride hemihydrate comprising converting a crystalline anhydrous solvate of paroxetine hydrochloride to a corresponding crystalline hemihydrate in the solid state. Method. This method is substantially different from the known technique of dissolution-precipitation sequence, specifically, the crystalline anhydrous solvate of paroxetine hydrochloride is water or a water miscible solvent (preferably And the wet crystalline solvate of paroxetine hydrochloride is heated at a temperature of 30-60 ° C. to completely dissolve the crystalline paroxetine hydrochloride hemihydrate. It is a manufacturing method including the process of converting. [Selection figure] None
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http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010260826-A
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