| abstract |
To create a novel isoquinoline derivative useful as a medicine and to find a new pharmacological action of the derivative. The compound of the formula [I] or a salt thereof is useful as a therapeutic agent for a disease involving Rho kinase, and particularly useful as a therapeutic agent for eye diseases such as glaucoma. Ring X is a benzene ring or aromatic heterocycle; Y is an isoquinoline ring group, R 1 and R 2 are hydrogen atoms or alkyl groups; R 3 and R 4 are halogen atoms, hydrogen atoms, alkyl groups, alkenyl groups, carboxy groups, An ester or amide thereof, alkylcarbonyl group, aryl group, arylcarbonyl group, amino group, alkylamino group, arylamino group, sulfonic acid group, nitro group, cyano group or aromatic having one or more nitrogen atoms in the ring A group heterocycle is shown. [Chemical 1] [Selection figure] None |