Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-072 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5088 |
classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate |
2006-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6da6b1177d565fd34d5eb1ad86a96533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0226cf1000c7d52f6d34ecd38e83cd9f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_84cb8f11156d89ac022544ea081e3024 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a874f5a28a762f50751b0a0e047fde8a |
publicationDate |
2007-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
JP-2007006891-A |
titleOfInvention |
An in vivo model for immunoequivalence |
abstract |
The present invention addresses the shortcomings encountered in human in vitro systems and provides a solution to the currently unresolved problem of ensuring the immunological equivalence of therapeutic antibodies. The present invention provides: a) producing a non-human animal wherein the standard antibody is transgenic, b) exogenous the transgenic non-human animal being a variant of the standard antibody which is transgenic of a) A method for determining the relative immunogenicity of an exogenous antibody variant comprising the steps of: contacting with a sex antibody; and c) determining the immune response of the transgenic non-human animal induced by the exogenous antibody of (b) I will provide a. [Selection figure] None |
priorityDate |
2005-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |