| abstract |
PROBLEM TO BE SOLVED: To provide a compound excellent in cancer cell growth inhibitory activity, metabolic stability, solubility and the like. A carboxamide derivative of the following formula [I], a tautomer or stereoisomer thereof, or a salt thereof is provided. [Chemical 1] L 1 , L 2 and L 3 are alkylene groups or absent, [A] is a hydroxy group or an electron-donating group-substituted aromatic ring, and [B] is a single ring or a condensed ring A ring, [C] is hydrogen or a hydroxy group, and [D] is a single ring or a condensed ring. The compound of the present invention has an excellent HDAC inhibitory activity, so that, in addition to an anticancer agent or an anticancer agent, for example, a therapeutic and / or ameliorating agent for a disease associated with cell proliferation, an effect enhancing agent for gene therapy, a cardiac hypertrophy ameliorating agent Application to various uses such as immunosuppressants, drugs that delay or prevent neurodegenerative diseases such as Huntington's disease caused by expansion of polyglutamine repeat sequences can also be expected. [Selection figure] None |