| abstract |
[Chemical 1] The present invention relates to variables R 1 , R 2 , R 3 , R 4 , R 5 , p, a 1 = a 2 −a 3 = a 4 , Z 1 −Z 2 , X and Y defined in claim 1. A novel indole derivative of formula (I), a pharmaceutically acceptable acid or base addition salt thereof, a stereoisomeric form thereof, an N-oxide form thereof or a quaternary ammonium thereof Regarding salt. The derivative exhibits binding affinity for dopamine receptors, in particular for dopamine D 2 , D 3 and D 4 receptors, has selective serotonin reuptake inhibition and 5-HT 1A agonists or moieties Acts as an agonist. The present invention relates to a pharmaceutical composition comprising a compound according to the invention, for the prevention and / or treatment of a series of psychotic and neurological disorders, in particular certain psychiatric disorders, in particular interpersonal phobia. And their use, and their method of manufacture. |