abstract |
The present invention relates to a compound of formula (0) or a salt thereof or a tautomer for use in the prevention or treatment of a disease symptom or condition, such as cancer mediated by cyclin dependent kinase and glycogen synthase kinase-3. Variants or N-oxides or solvates are provided. Formula (O). In formula (0): X is a R 1 —A—NR 4 — group or a 5 or 6 membered carbocyclic or heterocyclic ring; A is a bond, SO 2 , C═O, NR g (C═ O) or O (C═O), wherein R g is hydrogen or C 1-4 hydrocarbyl optionally substituted by hydroxy or C 1-4 alkoxy; Y is the bond or carbon atom length R 1 is hydrogen; a 3-12 ring membered carbocyclic or heterocyclic group; or halogen (eg fluorine), hydroxy, C 1-4 hydrocarbyloxy, amino, mono -Or di- C1-4 hydrocarbylamino, and a C1-8 hydrocarbyl group optionally substituted by one or more substituents selected from 3-12 ring member carbocyclic or heterocyclic groups, and Is 1 or 2 carbon atoms in the hydrocarbyl group, O, S, NH, SO, be optionally substituted by an atom or group selected from SO 2; R 2 is hydrogen; halogen; C 1-4 alkoxy (e.g., methoxy Or C 1-4 hydrocarbyl optionally substituted by halogen (eg fluorine), hydroxy or C 1-4 alkoxy (eg methoxy); R 3 is hydrogen and 3-12 ring membered carbon R 4 is selected from a ring or heterocyclic group; and R 4 is C 1-4 hydrocarbyl optionally substituted by hydrogen or halogen (eg, fluorine), hydroxy or C 1-4 alkoxy (eg, methoxy). [Chemical 1] |