abstract |
The present invention relates to a method for identifying an agonist that mimics or modulates the interaction between adiponectin and its receptor. In particular, the present invention relates to methods of mimicking or modulating adiponectin-T-cadherin interactions for treating diseases and conditions associated with adiponectin deficiency or excess. Examples of such diseases include obesity, anorexia nervosa, type I and type II diabetes, coronary artery disease, and atherosclerosis. The present invention also provides isolated adiponectin-T-cadherin complexes and methods for identifying polypeptides that interact with adiponectin. |