abstract |
This application relates to methods of inducing pancreatic endocrine phenotypes and functions, including pancreatic hormone production in non-pancreatic and non-endocrine cells, particularly hepatocytes / tissues. This ultimately results in PDX such as nucleic acids encoding PDX-1 polypeptide, neuro D polypeptide or betacellulin peptide in the presence of nicotinamide, EGF, activin A, HGF, exedin GLP-1 or betacellulin. Achieved by contacting the non-pancreatic and non-endocrine cells with the -1 inducer compound. |