| abstract |
The present invention relates to a novel class of hydroxamic acid derivatives having at least two aryl-containing functional groups, at least one of which is a quinolinyl, isoquinolinyl or benzyl moiety, attached to a hydroxamic acid group via a methylene chain About. Hydroxamic acid compounds can be used to treat cancer, such as brain tumors. Hydroxamic acid compounds can also inhibit histone deacetylases, selectively inducing terminal differentiation of neoplastic cells, cell growth arrest and / or apoptosis, thereby inhibiting the growth of such cells. Suitable for use. Thus, the compounds of the present invention are useful for treating patients with tumors characterized by neoplastic cell proliferation. The compounds of the invention are also used in the prevention and / or treatment of TRX-mediated diseases such as autoimmune diseases, allergic diseases and inflammatory diseases, and diseases of the central nervous system (CNS) such as neurodegenerative diseases. Useful. |