http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2006522055-A
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-02 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-26 |
filingDate | 2004-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2006-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2006522055-A |
titleOfInvention | Process for producing 5- (haloacetyl) -8- (substituted oxy)-(1H) -quinolin-2-ones |
abstract | The present invention relates to a process for producing 5- (α-haloacetyl) -8-substituted oxy- (1H) -quinolin-2-ones. The method comprises reacting (i) (a) 8-hydroxy- (1H) -quinolin-2-one with an acylating agent and a Lewis acid to give 5-acetyl-8-hydroxy- (1H) -quinoline-2. Or (b) reacting 8-hydroxy- (1H) -quinolin-2-one with an acylating agent to form 8-acetoxy- (1H) -quinolin-2-one; and In situ treating 8-acetoxy- (1H) -quinolin-2-one with Lewis acid to give 5-acetyl-8-hydroxy- (1H) -quinolin-2-one; or (c) 8- Reaction of acetoxy- (1H) -quinolin-2-one with Lewis acid to form 5-acetyl-8-hydroxy- (1H) -quinolin-2-one; (ii) prepared in step (i) 5 -Acetyl-8-hydroxy- (1H) -quinolin-2-one is represented by the formula RL ( Wherein R is a protecting group and L is a leaving group) in the presence of a base and a solvent to give 5-acetyl-8-substituted oxy- (1H) -quinoline-2- And (iii) reacting 5-acetyl-8-substituted oxy- (1H) -quinolin-2-one with a halogenating agent in the presence of a solvent to give 5- (α-haloacetyl) -8 -Forming a substituted oxy- (1H) -quinolin-2-one. |
priorityDate | 2003-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 74.