| abstract |
The hypoxia activated prodrug can be used to treat cancer when administered alone or in combination with one or more antineoplastic agents. A protected antineoplastic agent of formula Hyp-LN or Hyp-N, wherein Hyp is a hypoxic active agent; N is an antineoplastic agent; and L is a linking group. Protective anti-neoplastic agent. Hypoxic activators can be electron deficient nitrobenzene moieties, electron deficient nitrobenzoic acid amide moieties, nitroazole moieties, nitroimidazole moieties, nitrothiophene moieties, nitrothiazole moieties, nitrooxazole moieties, nitrofuran moieties, and nitropyrrole moieties. . |