abstract |
The present invention is a compound of formula (I) [Chemical 1] (Where X represents two hydrogen atoms, one sulfur atom, one oxygen atom, or one C 1-2 alkyl group and one hydrogen atom, Y represents a bond, a carbonyl group, an optionally substituted methylene group, R1 represents a 2, 3 or 4-pyridine ring or a 2, 4 or 5-pyrimidine ring, which ring may be optionally substituted; R2 represents a phenyl group or a naphthalene ring, and the phenyl group and naphthalene ring may be optionally substituted; R3 represents a hydrogen atom or a C 1-6 alkyl group, R4 represents a C 1-2 perhalogenated alkyl group or a C 1-3 halogenated alkyl group, R5 represents a hydrogen atom, a C 1-6 alkyl group or a halogen atom, n represents 0-3, and p + q = 0-3) And a substituted -pyrimidone derivative represented by the formula: The present invention also relates to a medicament used for preventive and / or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β such as Alzheimer's disease, comprising the above derivative or a salt thereof as an active ingredient. . |