| abstract |
The present invention relates to formula (I): [Wherein the symbols A, B, L 1 , L 2 , X 1 , X 2 , X 3 , X 4 , R 4 , R 5 , R 13 , R 14 , R 15 and R 16 are defined herein. Or a stereoisomer, or a pharmaceutically acceptable salt thereof. The compounds of formula (I) are selective for the blood coagulation cascade and / or contact activation system: eg, thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and / or the serine protease enzyme of plasma kallikrein It is useful as an inhibitor. In particular, it relates to compounds that are selective factor XIa inhibitors. The present invention also relates to a pharmaceutical composition containing these compounds and a method for treating a thromboembolic disease and / or an inflammatory disease using the same. |