| abstract |
The present invention relates to compositions and methods for removing tumor cells in a subject having at least one tumor site. More specifically, the method comprises contacting tumor cells in at least one tumor with a lytic factor in vivo under lytic conditions to form a treated tumor; and Applying sufficient in vivo stimulation to form a stimulated tumor. Compositions and methods for contracting local tumors or distant metastases or both in a subject are included. In a preferred embodiment, a method for contracting a tumor in a subject comprises contacting stimulated tumor cells with a lytic factor in vivo. Stimulation on tumor cells can increase the level of chaperone protein in the tumor cells. The combination of lysis factor and tumor cell stimulation causes contraction of the directly treated tumor, where the stimulation is applied either simultaneously or sequentially. In addition, distant or metastatic tumors that have not been directly treated can also be introduced by introducing a lytic factor into the stimulated tumor cells in the first tumor ("treated tumor" or "local tumor"). Will be reduced. Preferred method steps including introduction of lytic factors and stimulation of tumor cells are repeated to maximize tumor contraction effects. |