| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2502-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2533-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2500-72 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-02 |
| filingDate |
2004-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2006-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2006519021-A |
| titleOfInvention |
Production of dendritic cells from monocyte dendritic progenitors using GM-CSF in the absence of additional cytokines |
| abstract |
The present invention has determined that when monocytes are not activated, dendritic cells can be derived from a variety of sources including peripheral blood monocytes in the presence of GM-CSF alone without other cytokines. . By preventing activation, the monocytes do not require the presence of additional cytokines (eg, IL-4 or IL-13) to prevent differentiation into non-dendritic cell lineages. The immature DCs generated and maintained in this way were CD14 − and expressed high levels of CDla. Upon maturation by contact with drugs (eg, BCG and IFNγ), the cells are representative of mature dendritic cells purified by previous methods and cultured in the presence of GM-CSF and IL-4. It was determined to express surface molecules. Mature dendritic cells produced from non-activated monocytes and cultured with GM-CSF alone are suitable for use in dendritic cell-based immunotherapy methods (eg, in the treatment of diseases including cancer). Is suitable. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018523996-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114096260-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2018537949-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2010063404-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9303247-B2 |
| priorityDate |
2003-02-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |