| abstract |
The present invention generally modifies the glycosylation structure of recombinant proteins expressed in fungi or other lower eukaryotes, more closely to the glycosylation structure of proteins from higher mammals, particularly humans. It relates to a method of making it similar. The present invention also provides novel enzymes, nucleic acids encoding them, hosts engineered to express those enzymes, methods for producing modified glycoproteins in the hosts, and modified glycoproteins so produced About. |