| abstract |
The present invention provides compounds of the following formula (I) and pharmaceutically acceptable salts, hydrates or prodrugs thereof useful as serine protease inhibitors. [Wherein X is OH, O (alkyl), O (aryl), O (arylalkyl), NR 5 (aryl), or NR 5 (arylalkyl); W is hydrogen or (CR 7 R 8 ) q— W 1 ; W 1 is hydrogen or a bond having R 6 ; Z is a 5-membered heteroaryl group, 5- to 6-membered heterocyclo or cycloalkyl group, 9 to 10-membered dicyclic aryl or heteroaryl, or 6-membered aryl or hetero Aryl; and R 1 , R 2 , R 3 , R 5 , R 6 , R 7 and R 16 are as defined in the specification] |